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Overview
1 Improve Vaccines
2 Create New Vaccines
3 Control Insect Vectors
4 Improve Nutrition
5 Limit Drug Resistance
6 Cure Infection
7 Measure Health Status
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Goals
BROWSE THE GRAND CHALLENGES:
Goals
The 14 Grand Challenges serve 7 long-term goals to improve health in the developing world. Click below to learn more about specific challenges related to the seven goals.
Improve Vaccines
Improving delivery and stability of vaccines, as well as making them quicker and easier to administer, may one day save hundreds of thousands of young lives.
Learn more about this goal
Challenge 1: Create Effective Single Dose Vaccines That Can Be Used Soon After Birth
Challenge 2: Prepare Vaccines that Do Not Require Refrigeration
Challenge 3: Develop Needle-Free Delivery Systems
Create New Vaccines
Recent advances in medical research and technologies have the potential to help scientists move forward in the design and evaluation of new vaccines.
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Challenge 4: Devise Reliable Tests in Model Systems to Evaluate Live Attenuated Vaccines
Challenge 5: Solve How to Design Antigens for Effective, Protective Immunity
Challenge 6: Learn Which Immunological Responses Provide Protective Immunity
Control Insect Vectors
The sequencing of the genomes of insects and the pathogens they transmit provide new possibilities for developing chemical and genetic strategies to stop insects from passing on diseases.
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Challenge 7: Develop a Genetic Strategy to Deplete or Incapacitate a Disease-transmitting Insect Population
Challenge 8: Develop a Chemical Strategy to Deplete or Incapacitate a Disease-transmitting Insect Population
Improve Nutrition
Poor nutrition is a major global health problem. A promising long-term solution is to genetically modify crops that grow well in harsh climates so that they contain high levels of essential nutrients.
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Challenge 9: Create a Full Range of Optimal, Bioavailable Nutrients in a Single Staple Plant Species
Limit Drug Resistance
Developing drugs that target different components of a pathogen and finding new ways to deliver them in the body may one day minimize drug resistance.
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Challenge 10: Discover Drugs and Delivery Systems that Minimize the Likelihood of Drug Resistant Micro-organisms
Cure Infection
Using new knowledge and technologies, scientists are working on therapies that may one day help cure infections such as HIV, tuberculosis, and hepatitis.
Learn more about this goal
Challenge 11: Create Therapies that Can Cure Latent Infection
Challenge 12: Create Immunological Methods that can Cure Chronic Infections
Measure Health Status
Inadequate or expensive diagnostic tests to identify the cause of illness coupled with incomplete medical records can impede work in the developing world to target resources and disease control efforts.
Learn more about this goal
Challenge 13: Develop Technologies that Permit Quantitative Assessment of Population Health Status
Challenge 14: Develop Technologies that Allow Assessment of Multiple Conditions and Pathogens at Point of Care
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