Skip Navigation LinksHome > Projects by Technology
BROWSE THE GRAND CHALLENGES:

 Technology Priorities

Grand Challenges projects include research into new vaccines, drugs, diagnostic products, and other technologies for treating diseases that predominantly affect developing countries. Researchers are focusing on making these tools more effective, available, and affordable for the people who need them most. Learn about each of these technologies below:
Biomarkers
Diagnostics
Drugs
Nutrition
Vaccines
Vectors
Biomarkers:
Biomarkers are measurements that reveal key characteristics of disease, including pathogen status as well as human biological reactions to pathogens, drugs and vaccines. Biomarkers can be used to identify genes and proteins for new drug and vaccine development,  to evaluate drug efficacy, as well as to provide better diagnostics.  Identifying the "right" biomarkers can lead to earlier detection and more precise medical interventions to treat disease.
GOAL 2 | CHALLENGE 6
Protective Immunity Against Severe Malaria in Young Children
GOAL 2 | CHALLENGE 6
Biomarkers of Protective Immunity Against TB in the Context of HIV/AIDS in Africa
GOAL 2 | CHALLENGE 6
Immunity to Prevent Pneumococcal Transmission: Correlates of Protection and Herd Immunity
GOAL 2 | CHALLENGE 6
Learning From the Human Genome How Protective Immunity Against Malaria Works
GOAL 2 | CHALLENGE 6
Comprehensive Studies of Mechanisms of HIV Resistance in Highly Exposed Uninfected Women
GOAL 2 | CHALLENGE 6
Molecular Analysis and Modeling of HIV 1 Transmission, Containment, and Escape
BACK TO THE TOP
Diagnostics:
In the developing world, conclusively diagnosing illness can be difficult because today’s diagnostic tests are expensive or unavailable in resource-poor settings. Learn more about projects to develop diagnostic tools.
GOAL 7 | CHALLENGE 13
Population Health Metrics Research Consortium Project
GOAL 7 | CHALLENGE 14
A Point of Care Diagnostic System for the Developing World
GOAL 7 | CHALLENGE 14
Integrated Rapid Test Platforms Appropriate for the Developing World
BACK TO THE TOP
Drugs:
Disease-causing microbes often mutate and develop drug resistance. Developing drugs that target different components of a pathogen and finding new ways to deliver them in the body that might one day minimize drug resistance. Find out more about these drug-related projects.
GOAL 5 | CHALLENGE 10
Novel Therapeutics that Boost Innate Immunity to Treat Infectious Diseases
GOAL 5 | CHALLENGE 10
Natural Products Inhibit Intracellular Microorganisms Via Cellular Mechanisms
GOAL 6 | CHALLENGE 11
Drugs for Treatment of Latent Tuberculosis Infection
GOAL 6 | CHALLENGE 12
Immunological Strategies for Curing Chronic Hepatitis Virus Infections
GOAL 6 | CHALLENGE 12
Engineering Immunity Against HIV and other Dangerous Pathogens
BACK TO THE TOP
Nutrition:
Poor nutrition contributes to half of the nearly 10 million deaths that occur each year in children under 5. Creating nutrient-rich staple crops that can be grown in harsh climates is a promising long-term solution. Learn more about these nutrition-related projects.
GOAL 4 | CHALLENGE 9
Nutritionally Enhanced Sorghum for the Arid and Semi Arid Tropical Areas of Africa
GOAL 4 | CHALLENGE 9
Engineering Rice for High Beta Carotene, Vitamin E and Enhanced Fe and Zn Bioavailability
GOAL 4 | CHALLENGE 9
Optimisation of Bioavailable Nutrients in Transgenic Bananas
GOAL 4 | CHALLENGE 9
Improving Cassava for Nutrition, Health, and Sustainable Development
BACK TO THE TOP
Vaccines:
Millions of lives could be saved in the developing world by creating new vaccines that are effective after a single dose, that can be delivered without needles, and that do not require refrigeration. Learn about current projects related to vaccines.
GOAL 1 | CHALLENGE 1
Linking Innate and Specific Immunity to Develop Single Dose Vaccines for Neonates
GOAL 1 | CHALLENGE 1
A Live Recombinant Attenuated Salmonella Anti Pneumococcal Vaccine for Newborns
GOAL 1 | CHALLENGE 2
Optimization of Vaccine Stability Through High Throughput Formulation
GOAL 1 | CHALLENGE 2
Thermostable Vaccines with Improved Stability at Non Refrigerated Temperatures
GOAL 1 | CHALLENGE 2
Bacterial Spores as Vaccine Delivery Systems
GOAL 1 | CHALLENGE 3
Surface Modified Nanostructures as Delivery Vehicles for Transmucosal Vaccination
GOAL 1 | CHALLENGE 3
Nanoemulsions as Adjuvants for Nasal Spray Vaccines
GOAL 1 | CHALLENGE 3
Needle Free Vaccination Via Nanoparticle Aerosols
GOAL 1 | CHALLENGE 3
Development of a Targeted Mucosal Vaccine Delivery Technology
GOAL 1 | CHALLENGE 3
Needle Free Delivery of Stable, Respirable Powder Vaccine
GOAL 2 | CHALLENGE 4
Novel Mouse Models for Testing HIV and HCV Vaccines
GOAL 2 | CHALLENGE 4
Development of Novel Mouse Models for HIV and HCV Infection
GOAL 2 | CHALLENGE 4
A Humanized Mouse Model to Evaluate Live Attenuated Vaccine Candidates
GOAL 2 | CHALLENGE 5
Enhancing the Immunogenicity and Efficacy of Vectored Vaccines
GOAL 2 | CHALLENGE 5
Protective Genetically Attenuated P. Falciparum Sporozoite Vaccine
GOAL 2 | CHALLENGE 5
Novel Antigen Design and Delivery for Mucosal Protection Against HIV-1 Infection
GOAL 2 | CHALLENGE 5
Improved Vaccine Efficacy via Dendritic Cells and Flavivirus Vectors
GOAL 2 | CHALLENGE 6
Protective Immunity Against Severe Malaria in Young Children
GOAL 2 | CHALLENGE 6
Biomarkers of Protective Immunity Against TB in the Context of HIV/AIDS in Africa
GOAL 2 | CHALLENGE 6
Immunity to Prevent Pneumococcal Transmission: Correlates of Protection and Herd Immunity
GOAL 6 | CHALLENGE 12
Preclinical and Clinical Evaluation of a Post Exposure TB Vaccine
GOAL 6 | CHALLENGE 12
Novel Therapeutic Vaccines for Acute and Persistent Papillomavirus Infections
BACK TO THE TOP
Vectors:
Many serious diseases — including malaria and dengue fever — are spread by insects. Read about a number of promising projects aimed at delivering solutions that are safer, more effective, and more affordable than current methods for controlling disease-transmitting insects.

Learn about current projects related to insect vectors.
GOAL 3 | CHALLENGE 7
Homing Endonuclease Genes: New Tools for Mosquito Population Engineering and Control
GOAL 3 | CHALLENGE 7
Developing Coupled Transgenic Ribozyme and Insecticide Resistance Approaches to Establishing Dengue Virus Refractoriness in Natural Populations of Aedes aegypti Mosquitoes
GOAL 3 | CHALLENGE 7
Genetic Strategies for Control of Dengue Virus Transmission
GOAL 3 | CHALLENGE 7
Modifying Mosquito Population Age Structure to Eliminate Dengue Transmission
GOAL 3 | CHALLENGE 8
Molecular Approaches to Alter Olfactory Driven Behaviors of Insect Disease Vectors
GOAL 3 | CHALLENGE 8
Molecular Design of Selective Anticholinesterases for Mosquito Control
GOAL 3 | CHALLENGE 8
Disruption of Malaria Transmission by Chemical Manipulation of Anopheline Olfactory Responses
BACK TO THE TOP

 Research Map